CEREBROSPINAL-FLUID LEVELS OF SUPEROXIDE DISMUTASES IN NEUROLOGICAL DISEASES DETECTED BY SENSITIVE ENZYME IMMUNOASSAYS

We measured cerebrospinal fluid (CSF) levels of Cu/Zn superoxide dismu tase (Cu/Zn SOD) and Mn superoxide dismutase (Mn SOD) using enzyme imm unoassays in 196 neurological patients and 44 controls. The mean Cu/Zn SOD level was 55.8 +/- 27.6 (SD) ng/ml and the Mn SOD, 8.0 +/- 2.5 ng /ml in the controls. Cu/Zn SOD or Mn SOD levels showed neither age- no r sex-related differences in the controls. Both SODs were markedly ele vated in cerebrovascular diseases, bacterial meningitis and encephalit is. Mn SOD alone was significantly elevated in neurodegenerative disea ses. We compared SODs with CSF levels of neuron-specific enolase (NSE) and S-100b protein (S-100b) in cerebral infarction and bacterial meni ngitis. Both SODs were correlated with NSE and S-100b in patients with cerebral infarction, but not in those with bacterial meningitis. This means that elevations of SODs in CSF may not only be due to leakage f rom damaged nervous tissues, but also to the induction of SOD in lesio ns. We conclude that the mean SOD levels were elevated in various neur ological diseases, and their varied magnitudes may be associated with the underlying diseases.