Ij. Stewart et al., MONOCLONAL-ANTIBODIES DIRECTED AGAINST SURFACE AND INTRACELLULAR ANTIGENS OF MOUSE GRANULATED METRIAL GLAND-CELLS, Journal of immunological methods, 172(1), 1994, pp. 125-130
Rat monoclonal antibodies with reactivity directed against mouse GMG c
ells have been produced. One of the antibodies (GMG-1) reacts with a s
urface antigen of GMG cells and cross-reacts with T lymphocytes. Anoth
er (GMG-2) reacts with an intracellular antigen in GMG cells and with
asialo-GM1 positive cells in the spleen. Three antibodies (GMG-3, -4,
-5) bind to intracellular antigens in GMG cells. The cross-reactivity
of these antibodies is discussed with reference to the lineage relatio
nship of GMG cells to NK cells and T cells and the recent suggestion t
hat NK cells and T cells have a common progenitor cell. It is proposed
that GMG cells share this common progenitor cell but are otherwise in
dependent of the NK or T cell lineages.