MONOCLONAL-ANTIBODIES DIRECTED AGAINST SURFACE AND INTRACELLULAR ANTIGENS OF MOUSE GRANULATED METRIAL GLAND-CELLS

Rat monoclonal antibodies with reactivity directed against mouse GMG c ells have been produced. One of the antibodies (GMG-1) reacts with a s urface antigen of GMG cells and cross-reacts with T lymphocytes. Anoth er (GMG-2) reacts with an intracellular antigen in GMG cells and with asialo-GM1 positive cells in the spleen. Three antibodies (GMG-3, -4, -5) bind to intracellular antigens in GMG cells. The cross-reactivity of these antibodies is discussed with reference to the lineage relatio nship of GMG cells to NK cells and T cells and the recent suggestion t hat NK cells and T cells have a common progenitor cell. It is proposed that GMG cells share this common progenitor cell but are otherwise in dependent of the NK or T cell lineages.