Hb. Rahr et al., HEMOSTATIC ACTIVATION BEFORE AND AFTER SURGERY IN PATIENTS WITH AND WITHOUT GASTRIC MALIGNANCY, Thrombosis and haemostasis, 71(6), 1994, pp. 713-718
Pre- and postoperative plasma levels of Prothrombin Fragment 1 + 2 (F-
1+2), Thrombin-antithrombin III complex (TAT), Fibrinopeptide A (FpA),
Fibrin and Fibrinogen Degradation Products (FbDP, FgDP) and Soluble F
ibrin (SF) were measured in 40 patients undergoing gastric surgery in
order to compare patients operated for benign (n = 21) and malignant (
n = 19) disease. Plasma levels of F-1+2, TAT, FbDP and SF on the first
postoperative day were significantly higher than before operation. F-
1+2 and FbDP levels were further increased one week after surgery, at
which time FgDP levels were also higher than preoperatively. A signifi
cant postoperative increase in FpA levels was found only in patients w
ith malignant disease. When age was taken into consideration, signific
ant differences between patients with and without malignancy were foun
d only in the late postoperative period, as cancer patients had higher
FpA and FbDP levels one week after surgery and higher FbDP levels one
month after discharge from hospital.