CEFPODOXIME PROXETIL - A COMPREHENSIVE REVIEW

Cefpodoxime proxetil, a relatively new broad-spectrum third-generaatio n cephalosporin, has very good in vitro activity against Enterobacteri aceae, Hemophilus spp. and Moraxella spp., including beta-lactamase pr oducers and many strains resistant to other oral agents. It also has a ctivity against Gram-positive bacteria, especially against streptococc i. Cefpodoxime has no activity against enterococci. It is well tolerat ed and is one of the first third-generaation cephalosporins to be avai lable in oral form. While the compound has been used most widely in th e treatment of respiratory and urinary tract infections, its utility h as also been demonstrated in the treatment of skin structure infection s, acute otitis media, pharyngitis, tonsillitis, and sexually transmit ted diseases.