Gj. Lien et al., MODELING THE ACCUMULATION OF 3 WATERBORNE CHLORINATED ETHANES IN FATHEAD MINNOWS (PIMEPHALES-PROMELAS) - A PHYSIOLOGICALLY-BASED APPROACH, Environmental toxicology and chemistry, 13(7), 1994, pp. 1195-1205
A physiologically based kinetic model was used to predict the accumula
tion of a homologous series of chlorinated ethanes in fathead minnows
(Pimephales promelas). Uptake and accumulation of these compounds are
described in terms of a few fundamental physiological, morphological,
and physicochemical parameters. Chemical residues in 30-d-old fathead
minnows exposed to 1,1,2,2-tetrachloroethane, pentachloroethane, and h
exachloroethane were used to evaluate model performance. The predicted
and observed accumulations of the chlorinated ethanes were in close a
greement. A quantitative assessment of the major factors regulating th
e exchange of these compounds indicates that the cutaneous surface may
be an important route of uptake in small fish.