THE EFFECTS OF POLYSULFATED GLYCOSAMINOGLYCAN (ADEQUAN(R)) ON ACTIVATED PARTIAL THROMBO-PLASTIN TIME, PROTHROMBIN TIME, COMPLETE BLOOD-COUNT, BIOCHEMICAL PROFILE AND URINALYSIS IN CATS

The effects of a single intramuscular administration of polysulfated g lycosaminoglycan (PSGAG, Adequan(R)a) on activated partial thromboplas tin time (APTT), prothrombin time (PT), complete blood count (CBC), bi ochemical profile and urinalysis were determined in six adult cats. An injection of 5 mg/kg of PSGAG was given to three of the cats. and an injection of 25 mg/kg was given to the other three cats. Following a s even-day crossover interval, the doses were reversed. Serial blood and urine samples were collected over a 48-hour period after each injecti on. Administration of PSGAG resulted in a transient, dose-dependent in crease of APTT and PT. Prolonged bleeding from the venipuncture sites in the 25 mg/kg group was observed. Some of the CBC, biochemical profi le, and urinalysis values changed following treatment, but clinically significant adverse reactions were not noticed.