FAILURE OF MONOIODOACETATE TO INDUCE LAMENESS IN DOGS

Intra-articular sodium monoiodoacetate (MIA) has been shown to consist ently induce a reproducible model of chronic arthritis in rats, chicke ns, guinea pigs, rabbits and horses. The purpose of this study was to determine if intra-articular injections of MIA would produce clinical signs of degenerative joint disease in dogs. Two different doses of MI A were injected into the stifle joints of normal dogs. Changes in limb function were evaluated by physical examination and force platform ga it analysis. The dogs were evaluated weekly for three weeks, after whi ch the MIA injections were repeated. They were again evaluated weekly for an additional two weeks. Significant changes in limb function were not found during any portion of the study as determined by physical e xamination of the injected joints and force platform gait analysis. In tra-articular MIA, at the doses used in this study, did not induce lam eness nor clinical signs of degenerative joint disease.