EFFECT OF THYMOPENTIN (TP-5) ON THYROTROPIN (TSH), PROLACTIN (PRL) AND GROWTH-HORMONE (GH) SECRETION IN MALE-RATS

Authors
KASK A RAGO L MANNISTO PT
Citation
A. Kask et al., EFFECT OF THYMOPENTIN (TP-5) ON THYROTROPIN (TSH), PROLACTIN (PRL) AND GROWTH-HORMONE (GH) SECRETION IN MALE-RATS, Neuro endocrinology letters, 16(3), 1994, pp. 165-170
Citations number
23
Categorie Soggetti
Endocrynology & Metabolism",Neurosciences
Journal title
Neuro endocrinology letters → ACNP
ISSN journal
0172780X
Volume
16
Issue
3
Year of publication
1994
Pages
165 - 170
Database
ISI
SICI code
0172-780X(1994)16:3<165:EOT(OT>2.0.ZU;2-C
Abstract
The effects of the intracerebroventricularly (i.c.v.) and intraperiton eally (i.p.) infused pentapeptide thymopentin [Arg-Lys-Asp-Val-Tyr] (0 .1, 1, 10, and 20 mu g) and (0.1, 1.0, and 10.0 mu g/kg), respectively , were studied on plasma GH, PRL and TSH concentrations. No significan t changes on TSH, PRL and GH secretion was found 15 min after acute i. c.v. infusions while i.p. administration of TP-5 (0.1 mu g/kg) lowered TSH levels. TP-5 (0. 1 and 1 mu g/kg, i.p.) did not modify the TRH-in duced TSH levels.