EFFECT OF SEROTONIN DEPLETION ON THE HYPOTHALAMO-HYPOPHYSEAL-GONADOTROPIC ACTIVITY IN RAT FETUSES

Authors
SAPRONOVA A ADAMSKAYA E BABICHEV V PROSHLYAKOVA E UGRUMOV M
Citation
A. Sapronova et al., EFFECT OF SEROTONIN DEPLETION ON THE HYPOTHALAMO-HYPOPHYSEAL-GONADOTROPIC ACTIVITY IN RAT FETUSES, Neuro endocrinology letters, 16(3), 1994, pp. 201-207
Citations number
15
Categorie Soggetti
Endocrynology & Metabolism",Neurosciences
Journal title
Neuro endocrinology letters → ACNP
ISSN journal
0172780X
Volume
16
Issue
3
Year of publication
1994
Pages
201 - 207
Database
ISI
SICI code
0172-780X(1994)16:3<201:EOSDOT>2.0.ZU;2-T
Abstract
The luteinizing hormone-releasing hormone (LH-RH) content highly decre ased in the hypothalamus of male fetuses, but not of female fetuses un der serotonin (5-HT) deficiency. This coincided with an increase of th e LH level in male plasma. The testosterone action on the LH-RH or LK secretions could be excluded as there was no change in testosterone le vel in testis and plasma. The possible influence of the 5-HT deficienc y on the developing LH-RH system and, thus, on the hypothalamo-hypophy sial-gonadotropic axis is discussed.