CONTROLLED TRIAL OF TAMOXIFEN IN PATIENTS WITH ADVANCED HEPATOCELLULAR-CARCINOMA

Thirty-six consecutive patients with advanced hepatocellular carcinoma and chronic liver disease were randomly allocated to two groups: grou p I included 20 patients who were treated with 10 mg bid. tamoxifen an d group II with 16 nontreated patients. The two groups were homogeneou s according to clinical and analytical data. Survival curves in the ta moxifen-treated patients improved significantly when compared with the non-treated group (p=0.01). Cumulative survival at the end of the fir st year was 48.5% in the treated patients and 9.1% in controls. Median survival was 261 days in the treated group vs. 172 in the non-treated group (p<0.05). Complications of cirrhosis and worsening of the perfo rmance status test occurred less in the treated patients than in the c ontrols, but not significantly so. Tamoxifen was well tolerated and no marked side effects were observed. In this series, tamoxifen improved survival in patients with advanced hepatocellular carcinoma. (C) Jour nal of Hepatology.