Xm. Chen et Nh. Haunerland, FATTY-ACID-BINDING PROTEIN EXPRESSION IN LOCUST FLIGHT-MUSCLE - INDUCTION BY FLIGHT, ADIPOKINETIC HORMONE, AND LOW-DENSITY LIPOPHORIN, Insect biochemistry and molecular biology, 24(6), 1994, pp. 573-579
Fatty acid binding protein (FABP) is a major cytosolic protein in the
flight muscle of the adult desert locust, Schistocerca gregaria. While
it is normally expressed at high rates only at the beginning of the a
dult stage, a marked increase in FABP mRNA accumulation can be induced
by flight. Extended flight leads to a 10-fold increase of FABP mRNA w
ithin 12 h. Injection of adipokinetic hormone which mobilizes lipid de
livery also stimulates FABP transcription in a dose-dependent manner.
FABP mRNA reaches its maximum 16 h after treatment and returns to its
base level within 48 h. Purified low density lipophorin, when injected
into resting locusts, causes a similar increase as adipokinetic hormo
ne or flight, suggesting that the additional supply of fatty acids is
the ultimate cause for the observed induction of FABP expression.