The paper provides the follow-up findings of patients with cardiac myx
omas according to the presence or absence of the myxomal syndrome. It
is shown that it is a multiorgan abnormality wherein the cardiac myxom
as that are prone to primarily multiple growth, extraseptal and/or mul
tifocal fixation are associated with the changes in the hypothalamus-p
ituitary-adrenal and renin-angiotensin-aldosterone systems, skin spott
y pigmentation, neoplasms in the viscera, skin, and fat. These specifi
c features emphase the predictive value of the myxomal syndrome, which
predetermines that its early diagnosis should be made in routine clin
ical practice.