SEX-DIFFERENCES IN CLINICOPATHOLOGICAL FEATURES OF PERIPHERAL T-1, ADENOCARCINOMA OF THE LUNG

Clinicopathological features of surgically-treated peripheral T1 adeno carcinoma of the lung were compared between 30 females and 26 males, a ad the following sex differences were observed; 1) Females were younge r than males, 2) There was a higher percentage of smokers among males, 3) The acinar histologic subtype was less frequently found in females , 4) Well differentiated tumors were more frequently found in females, 5) K-ras gene mutations were observed only in males, 6) Prognosis was slighty better in females. As to other factors such as N-factor, rumo r ploidy or central fibrosis, there was no statistical difference betw een the two groups. Although we were not able to explain the causes fo r the above sex differences, it was speculated that smoking was mainly responsible for them.