MORPHOLOGICAL TRANSFORMATION OF SYRIAN-HAMSTER EMBRYO CELLS BY PSEUDORABIES VIRUS-RELATED GROWTH-FACTOR

Authors
DUSINSKA M LESKO J GOLAIS F SLAMENOVA D
Citation
M. Dusinska et al., MORPHOLOGICAL TRANSFORMATION OF SYRIAN-HAMSTER EMBRYO CELLS BY PSEUDORABIES VIRUS-RELATED GROWTH-FACTOR, Cancer letters, 79(2), 1994, pp. 125-129
Citations number
22
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
79
Issue
2
Year of publication
1994
Pages
125 - 129
Database
ISI
SICI code
0304-3835(1994)79:2<125:MTOSEC>2.0.ZU;2-N
Abstract
Syrian hamster embryo (SHE) clonal morphological transformation assay has been used for the in vitro testing of transforming activity of Pse udorabies virus (PRV) related growth factor (PRGF). It was found that PRGF induces morphologically transformed colonies of SHE cells in the wide titer scale (in the range 1 x 10(7) to 1 X 10(13) U/ml). The conc entrations of PRGF which induced the transforming phenotype of SHE cel ls in the colonies did not cause significant cytotoxic effect.