M. Dusinska et al., MORPHOLOGICAL TRANSFORMATION OF SYRIAN-HAMSTER EMBRYO CELLS BY PSEUDORABIES VIRUS-RELATED GROWTH-FACTOR, Cancer letters, 79(2), 1994, pp. 125-129
Syrian hamster embryo (SHE) clonal morphological transformation assay
has been used for the in vitro testing of transforming activity of Pse
udorabies virus (PRV) related growth factor (PRGF). It was found that
PRGF induces morphologically transformed colonies of SHE cells in the
wide titer scale (in the range 1 x 10(7) to 1 X 10(13) U/ml). The conc
entrations of PRGF which induced the transforming phenotype of SHE cel
ls in the colonies did not cause significant cytotoxic effect.