CLOZAPINE TREATMENT AND ITS EFFECT ON NEUROENDOCRINE RESPONSES INDUCED BY THE SEROTONIN AGONIST, M-CHLOROPHENYLPIPERAZINE

Authors
KAHN RS DAVIDSON M SIEVER LJ SEVY S DAVIS KL
Citation
Rs. Kahn et al., CLOZAPINE TREATMENT AND ITS EFFECT ON NEUROENDOCRINE RESPONSES INDUCED BY THE SEROTONIN AGONIST, M-CHLOROPHENYLPIPERAZINE, Biological psychiatry, 35(12), 1994, pp. 909-912
Citations number
9
Categorie Soggetti
Psychiatry
Journal title
Biological psychiatry → ACNP
ISSN journal
00063223
Volume
35
Issue
12
Year of publication
1994
Pages
909 - 912
Database
ISI
SICI code
0006-3223(1994)35:12<909:CTAIEO>2.0.ZU;2-2
Abstract
The effects of clozapine treatment on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine (mCPP) were examin ed, mCPP and placebo were administered after a 2-week drug-free period and again after 5 weeks of clozapine treatment in nine schizophrenic inpatients. Adrenocorticotropic hormone (ACTH), prolactin, and mCPP le vels were measured. Clozapine treatment completely blocked mCPP-induce d ACTH and prolactin release suggesting that clozapine blocks serotoni n receptors that mediate these hormone responses.