Rs. Kahn et al., CLOZAPINE TREATMENT AND ITS EFFECT ON NEUROENDOCRINE RESPONSES INDUCED BY THE SEROTONIN AGONIST, M-CHLOROPHENYLPIPERAZINE, Biological psychiatry, 35(12), 1994, pp. 909-912
The effects of clozapine treatment on neuroendocrine responses induced
by the serotonin agonist, m-chlorophenylpiperazine (mCPP) were examin
ed, mCPP and placebo were administered after a 2-week drug-free period
and again after 5 weeks of clozapine treatment in nine schizophrenic
inpatients. Adrenocorticotropic hormone (ACTH), prolactin, and mCPP le
vels were measured. Clozapine treatment completely blocked mCPP-induce
d ACTH and prolactin release suggesting that clozapine blocks serotoni
n receptors that mediate these hormone responses.