COMPARATIVE H-3 CCK-8S BINDING-STUDIES ON CCKB-TYPE RECEPTORS IN GUINEA-PIG CORTEX AND CONTINUOUS CELL-LINES

Authors
KAUFMANN R SCHONEBERG T HENKLEIN P BOOMGAARDEN M SOHR D OTT T
Citation
R. Kaufmann et al., COMPARATIVE H-3 CCK-8S BINDING-STUDIES ON CCKB-TYPE RECEPTORS IN GUINEA-PIG CORTEX AND CONTINUOUS CELL-LINES, Neuropeptides, 26(6), 1994, pp. 429-433
Citations number
17
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism
Journal title
Neuropeptides → ACNP
ISSN journal
01434179
Volume
26
Issue
6
Year of publication
1994
Pages
429 - 433
Database
ISI
SICI code
0143-4179(1994)26:6<429:CHCBOC>2.0.ZU;2-B
Abstract
The present study was undertaken to compare binding characteristics of CCKB-type receptors in guinea-pig cortex, Jurkat T-cells, GH3 cells a nd C-6 cells. The rank order of potency of a variety of CCK agonists a nd antagonists in inhibiting specific [H-3]CCK-8S binding was highly c orrelated for the 4 CCKB receptor models as demonstrated by a computer -assisted statistical analysis. Taking the ligand binding profiles as the criterion it is concluded that CCKB receptors in guinea-pig cortex , Jurkat T-cells, pituitary GH3 cells and rat glioma C-6 cells share i dentical pharmacological properties.