POLYMORPHISM OF MET AND D7S23 LOCI LINKED TO THE CYSTIC-FIBROSIS GENEIN BASHKIR AND KOMI POPULATIONS

The allelic polymorphism of MET and D7S23 loci closely linked to the c ystic fibrosis gene was studied in two Bashkir ethnic groups and the K omi population using the polymerase chain reaction. The distribution o f the allelic frequencies of the MET locus in Bashkir and Komi populat ions does not differ significantly from that in populations from Lenin grad, Kiev northwest Europe and North America. With the D7S23 locus, a similar distribution of allelic frequencies was found among Bashkir, Komi, Lithuanian and Buryat populations, but a significant difference was observed from the allelic frequencies at this locus in populations from Leningrad and Azerbaijan. Genetic distances between the investig ated Bashkir and Komi populations were specified according to the data on the allelic frequencies of the MET and D7S23 loci, and a comparati ve analysis with the genetic distances obtained on the basis of the al lele frequencies of the biochemically polymorphic systems of ABO. Rhes us, haptoglobin protein and acidic erythrocytic phosphatase was carrie d out.