MYELODYSPLASIA FOLLOWING PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA - EVIDENCE FOR THE EMERGENCE OF A SEPARATE CLONE

Authors
VANKAMP H SMIT JW VANDENBERG E HALIE MR VELLENGA E
Citation
H. Vankamp et al., MYELODYSPLASIA FOLLOWING PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA - EVIDENCE FOR THE EMERGENCE OF A SEPARATE CLONE, British Journal of Haematology, 87(2), 1994, pp. 399-400
Citations number
13
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
87
Issue
2
Year of publication
1994
Pages
399 - 400
Database
ISI
SICI code
0007-1048(1994)87:2<399:MFPH-E>2.0.ZU;2-C
Abstract
patient with paroxysmal nocturnal haemoglobinuria (PNH) who developed a myelodysplastic syndrome (MDS) is described. After the onset of myel odysplasia the neutrophils of the patient fully expressed GPI-linked p roteins. It is concluded that the myelodysplasia does not originate fr om transformed PNH stem cells, but represents the emergence of a separ ate clone arising from an injured marrow.