DETECTION OF RESISTANCE PROTEINS IN MATCHED PRIMARY LUNG-TUMORS AND LYMPH-NODE METASTASES

The expression of several resistance markers (P-glycoprotein, glutathi one S-transferase-pi, thymidylate synthase, dihydrofolate reductase) w as analyzed in matched primary tumors and lymph node metastases from 2 1 patients with lung cancer using immunohistochemistry. The analysis s howed that expression of these resistance proteins is generally congru ent in primary lung cancer and simultaneously resected lymph node meta stases. This suggests that in general the resistance of a primary tumo r predicts for the resistance of the metastases and vice versa.