PAPILLOMAVIRUS-ASSOCIATED BALANOPOSTHITIS

Citation
A. Wikstrom et al., PAPILLOMAVIRUS-ASSOCIATED BALANOPOSTHITIS, Genitourinary medicine, 70(3), 1994, pp. 175-181
Citations number
51
Categorie Soggetti
Urology & Nephrology","Public, Environmental & Occupation Heath","Dermatology & Venereal Diseases
Journal title
ISSN journal
02664348
Volume
70
Issue
3
Year of publication
1994
Pages
175 - 181
Database
ISI
SICI code
0266-4348(1994)70:3<175:PB>2.0.ZU;2-R
Abstract
Objective-To assess whether there might be an association between geni tal papillomavirus infection (GPVI) and balanoposthitis. Design-Retros pective HPV DNA examination of biopsy specimens from 23 men suffering from balanoposthitis and exhibiting acetowhite lesions that were penos copically and histologically concurrent with HPV infection. Setting-Th e STD clinics at Karolinska Hospital and South Hospital, Stockholm, Sw eden. Participitants-Randomly selected men attending with long-lasting and/or recurrent penile symptoms and exhibiting a clinical picture of balanoposthitis, who revealed a penoscopical and histopathological pi cture of epidermal lesions that were concordant with accepted criteria for typical or conspicuous GPVI. Asymptomatic controls were selected retrospectively on the basis of identical penoscopy and histology crit eria. Results-A history of previous condylomata was obtained in eight (35%) of 23 men. At penoscopic evaluation tiny condylomatous lesions w ere observed in five (22%) patients. The in situ hybridisation (ISH) a ssay using specific probes for the HPV types 6/11, 16/18, 31/33 and 42 was positive in 13/23 (56%) of the patient samples, but in only 26% o f the 19 control samples. In patient biopsies the oncogenic HPV types 16/18 and/or 31/33 were found in 7/13 samples, whereas HPV 6/11 and/or 42 were present in another six cases. PCR performed on the ten ISH ne gative patient biopsies, were negative in all cases. Conclusion-Sympto ms included redness, itching, burning, tenderness, dyspareunia, fissur ing and in two cases penile oedema and inguinal adenopathy. All patien ts fulfilled penoscopical and histopathological criteria for HPV infec tion. We demonstrate some tentative evidence that HPV might be associa ted with long-lasting balanoposthitis, although our data still are cir cumstantial for a causative association. The results also elucidate th e diversity in clinical presentation of GPVI.