ON STEROIDS .372. SYNTHESIS OF SOME EPITESTOSTERONE ANALOGS

Authors
CHODOUNSKA H SLAVIKOVA B KASAL A
Citation
H. Chodounska et al., ON STEROIDS .372. SYNTHESIS OF SOME EPITESTOSTERONE ANALOGS, Collection of Czechoslovak Chemical Communications, 59(2), 1994, pp. 435-443
Citations number
18
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
59
Issue
2
Year of publication
1994
Pages
435 - 443
Database
ISI
SICI code
0010-0765(1994)59:2<435:OS.SOS>2.0.ZU;2-C
Abstract
11beta-Hydroxyandrost-4-ene-3,17-dione (III) was converted into a pote ntial metabolite of epitestosterone - 11beta, 17alpha-dihydroxyandrost -4-en-3-one (II) in 5 steps, including the inversion of configuration of a 17beta-hydroxy group. This inversion was not feasible in the prep aration of the analogues X, XIV, XX, and XXII, where the 17alpha-hydro xy group was introduced first and only then was the rest of the molecu le modified.