PERSISTENT SHORT-TERM-MEMORY DEFICITS IN HEBB-WILLIAMS MAZE PERFORMANCE ARE SHOWN BY RATS WITH UNILATERAL ENTORHINAL CORTEX LESIONS

The spatial abilities of adult, male Sprague-Dawley rats in the Hebb-W illiams maze were examined at 6 months after unilateral electrolytic e ntorhinal cortex lesions. Compared with sham-operated rats, their perf ormance was impaired in both initial entry and repeat entry errors ove r 12 consecutive problems, using immediate starting replacement for th e 6 trials per problem. The configurations of the 12 maze problems are independent, and deficits were seen over the entire course of the tes ting. This study indicates that Hebb-Williams maze performance deficit s after unilateral entorhinal cortex lesion are persistent and can be seen up to 6 months after injury.