TOXICOKINETIC MIXTURE INTERACTIONS BETWEEN 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN AND 2,2',4,4',5,5'-HEXACHLOROBIPHENYL IN THE LIVER OF NEONATAL RATS AFTER PRENATAL AND POSTNATAL EXPOSURE
J. Dejongh et al., TOXICOKINETIC MIXTURE INTERACTIONS BETWEEN 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN AND 2,2',4,4',5,5'-HEXACHLOROBIPHENYL IN THE LIVER OF NEONATAL RATS AFTER PRENATAL AND POSTNATAL EXPOSURE, Chemosphere, 28(9), 1994, pp. 1581-1588
Pregnant rats received single oral doses of either 1.39 mug 2,3,7,8-te
trachlorodibenzo-p-dioxin (TCDD)/kg, 164 mg 2,2',4,4',5,5'-hexachlorob
iphenyl (HxCB)/kg, or a mixture of both compounds at day 16 of gestati
on. The hepatic deposition of the compounds as well as CYP1A dependent
7-ethoxyresorufin-O-deethylation (EROD) and CYP2B dependent 7-pentoxy
resorufin-O-depentylation (PROD) activity were studied in the mothers
and offspring at day 10 after delivery. The HxCB deposition in the liv
ers of mothers and offspring was approximately doubled when this compo
und was coadministered with TCDD but HxCB coadministration did not inf
luence hepatic TCDD deposition. It is concluded that the mechanisms be
hind the toxicokinetic interactions between PCDDs and di-orthosubstitu
ted PCBs in the liver are probably different for both groups of compou
nds.