R. Frei et al., ANTIMICROBIAL ACTIVITY OF FK-037, A NEW BROAD-SPECTRUM CEPHALOSPORIN - INTERNATIONAL IN-VITRO COMPARISON WITH CEFEPIME AND CEFTAZIDIME, Diagnostic microbiology and infectious disease, 18(3), 1994, pp. 167-173
The in vitro activity of FK-037, a new parenteral 7-aminothiazolyl-met
hoxyimino cephalosporin, was compared with cefepime and ceftazidime ag
ainst 6094 aerobic isolates collected in six medical centers worldwide
. FK-037 demonstrated potent activity against the Enterobacteriaceae f
amily except for some Enterobacter spp., Providencia spp., and Serrati
a liquefaciens (MIC(90)s, greater than or equal to 16 mu g/ml). Agains
t nonenteric Gram-negative bacilli, all compounds tested showed simila
r, but more limited activity. The FK-037 MIC(50)s for Pseudomonas spp.
and P. aeruginosa were 2 and 4 mu g/ml, respectively. The least susce
ptible organisms were Xanthomonas maltophilia, enterococci, and Bacill
us spp. (MIC(50)s, > 16 mu g/ml), followed by Flavobacterium spp., oth
er nonenterics, and oxacillin-resistant Staphylococcus aureus (MIC(50)
s, 16 mu g/ml). Good FK-037 activity was observed against oxacillin-su
sceptible staphylococci as well as against beta-hemolytic and viridans
-group streptococci (MIC(90) range, less than or equal to 0.12 to 2 mu
g/ml). While FK-037 was slightly more active than cefepime against Cr
am-positive organisms, enteric bacilli were most susceptible to cefepi
me. Overall, the antibacterial spectrum of both FK-037 and cefepime wa
s superior to ceftazidime. -