PROTECTIVE EFFECT OF CISAPRIDE AGAINST INDOMETHACIN-INDUCED OBSTRUCTION OF THE GASTRIC-MUCOSAL HEMODYNAMICS IN RATS

Authors
YOKOYAMA T KITAZAWA T ISHII A OGIHARA T SATO N KARASAWA A
Citation
T. Yokoyama et al., PROTECTIVE EFFECT OF CISAPRIDE AGAINST INDOMETHACIN-INDUCED OBSTRUCTION OF THE GASTRIC-MUCOSAL HEMODYNAMICS IN RATS, Japanese Journal of Pharmacology, 65(2), 1994, pp. 171-173
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Japanese Journal of Pharmacology → ACNP
ISSN journal
00215198
Volume
65
Issue
2
Year of publication
1994
Pages
171 - 173
Database
ISI
SICI code
0021-5198(1994)65:2<171:PEOCAI>2.0.ZU;2-H
Abstract
We investigated the effect of cisapride, a gastroprokinetic agent, on the obstructed gastric mucosal hemodynamics induced by indomethacin us ing an organ reflectance spectrophotometry system in rats. Indomethaci n (10 mg/kg, i.v.) reduced both the gastric mucosal blood volume and t he gastric mucosal blood oxygenation. Pretreatment with cisapride (0.1 mg/kg, i.v.) prevented these deteriorations. The presently-clarified gastric mucosal protective effect of cisapride may contribute to its t herapeutic efficacy.