QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF BENZOYLIMINOTHIADIAZOLINE DERIVATIVES AS ANGIOTENSIN-II RECEPTOR ANTAGONISTS

Authors
HIRATA T GOTO S TAMURA K OKUHIRA M NAGAO Y
Citation
T. Hirata et al., QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF BENZOYLIMINOTHIADIAZOLINE DERIVATIVES AS ANGIOTENSIN-II RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 7(4), 1997, pp. 385-388
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
4
Year of publication
1997
Pages
385 - 388
Database
ISI
SICI code
0960-894X(1997)7:4<385:QSOB>2.0.ZU;2-G
Abstract
Syntheses and biological activities of benzoyliminothiadiazoline deriv atives which have potential affinities for angiotensin II receptor are described. The contributions of substituent (R(1)) on the benzene rin g in benzoyl moiety and 5-position substituent (R(2)) on the 1,3,4-thi adiazoline ring were quantitatively investigated. (C) 1997, Elsevier S cience Ltd.