A SIMPLE METHOD FOR THE SYNTHESIS OF 2'-O-ALKYLGUANOSINE DERIVATIVES

Authors
GROTLI M DOUGLAS M BEIJER B ERITJA R SPROAT B
Citation
M. Grotli et al., A SIMPLE METHOD FOR THE SYNTHESIS OF 2'-O-ALKYLGUANOSINE DERIVATIVES, Bioorganic & medicinal chemistry letters, 7(4), 1997, pp. 425-428
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
4
Year of publication
1997
Pages
425 - 428
Database
ISI
SICI code
0960-894X(1997)7:4<425:ASMFTS>2.0.ZU;2-0
Abstract
A new synthetic route has been devised for the preparation of 2'-O-alk yl guanosine derivatives. Utilizing a strategy of minimal protection, the alkylation was performed on partly protected guanosine using an al kyl halide and a sterically hindered strong organic base. (C) 1997, El sevier Science Ltd.