SYNTHESES OF UNSTABLE DIOL EPOXIDE METABOLITES OF THE POTENT CARCINOGENS 7-METHYLBENZ[A]ANTHRACENE AND 12-METHYLBENZ[A]ANTHRACENE

Authors
HARVEY RG CORTEZ C KISELYOV A
Citation
Rg. Harvey et al., SYNTHESES OF UNSTABLE DIOL EPOXIDE METABOLITES OF THE POTENT CARCINOGENS 7-METHYLBENZ[A]ANTHRACENE AND 12-METHYLBENZ[A]ANTHRACENE, Bioorganic & medicinal chemistry letters, 7(4), 1997, pp. 443-446
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
4
Year of publication
1997
Pages
443 - 446
Database
ISI
SICI code
0960-894X(1997)7:4<443:SOUDEM>2.0.ZU;2-L
Abstract
Stereospecific syntheses of the anti- and syn-diol epoxides of 7- and 12-methylbenz[a] anthracene, suspected as active metabolites of the pa rent PAHs but previously thought to be too chemically reactive and uns table to isolate, are described and the pure compounds are shown to be moderately stable. (C) 1997, Elsevier Science Ltd.