REPLACEMENT OF THE PHOSPHODIESTER LINKAGE IN OLIGONUCLEOTIDES BY AN AMIDE - EFFECT OF BACKBONE LENGTH ON DUPLEX STABILITY WITH RNA COMPLEMENT

Authors
DEMESMAEKER A JOUANNO C WOLF RM WENDEBORN S
Citation
A. Demesmaeker et al., REPLACEMENT OF THE PHOSPHODIESTER LINKAGE IN OLIGONUCLEOTIDES BY AN AMIDE - EFFECT OF BACKBONE LENGTH ON DUPLEX STABILITY WITH RNA COMPLEMENT, Bioorganic & medicinal chemistry letters, 7(4), 1997, pp. 447-452
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
4
Year of publication
1997
Pages
447 - 452
Database
ISI
SICI code
0960-894X(1997)7:4<447:ROTPLI>2.0.ZU;2-P
Abstract
Five dimers containing amide linkages instead of the natural phosphodi ester linkage were synthesized and incorporated into oligonucleotides. The length of the amide backbone was varied. The hybridization proper ties of the modified oligonucleotides with RNA complements and their c onformational analysis are described and compared to previously report ed amide containing oligonucleotides. In addition, the synthesis of a thioamide phosphoramidite dimer is reported. (C) 1997, Elsevier Scienc e Ltd.