DIGITALIS-LIKE COMPOUNDS - SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-BETA-(AMINOALKYLTHIO) DERIVATIVES

Authors
GOBBINI M BENICCHIO A PADOANI G TORRI M MELLONI P
Citation
M. Gobbini et al., DIGITALIS-LIKE COMPOUNDS - SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-BETA-(AMINOALKYLTHIO) DERIVATIVES, Bioorganic & medicinal chemistry letters, 7(4), 1997, pp. 469-472
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
4
Year of publication
1997
Pages
469 - 472
Database
ISI
SICI code
0960-894X(1997)7:4<469:DC-SAB>2.0.ZU;2-9
Abstract
The synthesis and the binding affinities to the digitalis receptor on the Na+,K+-ATPase of a series of 3 beta-(aminoalkylthio) digitalis der ivatives are described. In most cases these derivatives showed a highe r binding affinity than that of the corresponding 3 beta-hydroxy and 3 beta-mercapto parent compounds. (C) 1997, Elsevier Science Ltd.