EFFECTS OF CPG METHYLATION TO DOUBLE-STRANDED DNA BREAKS BY CU(II)-PODOPHYLLOTOXIN DERIVATIVE COMPLEXES

Authors
TAWA R TAKAMI M IMAKURA Y LEE KH SAKURAI H
Citation
R. Tawa et al., EFFECTS OF CPG METHYLATION TO DOUBLE-STRANDED DNA BREAKS BY CU(II)-PODOPHYLLOTOXIN DERIVATIVE COMPLEXES, Bioorganic & medicinal chemistry letters, 7(4), 1997, pp. 489-494
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
4
Year of publication
1997
Pages
489 - 494
Database
ISI
SICI code
0960-894X(1997)7:4<489:EOCMTD>2.0.ZU;2-K
Abstract
Site-specific double stranded DNA breaks by . OH radicals generated fr om podophyllotoxin related compounds in the presence of Cu(II) ion wer e investigated and the neighboring effects of. 5-methylcytosine oil do uble stranded DNA cleavage, especially on methylated CpG sites, were e valuated. (C) 1997, Elsevier Science Ltd.