EFFECT OF A NEW CHOLECYSTOKININ RECEPTOR ANTAGONIST (KSG-504) ON THE EARLY-STAGE OF THE HEALING-PROCESS IN ACUTE-PANCREATITIS INDUCED IN RATS BY THE CLOSED DUODENAL LOOP TECHNIQUE

Creation of a closed duodenal loop produced edematous acute pancreatit is within 6 h and hemorrhagic acute pancreatitis within 12 h in male S prague-Dawley rats. The pancreatitis thus established tended to improv e after releasing the loop. We investigated the effect of a new cholec ystokinin receptor antagonist, KSG 504, on the healing process in edem atous and hemorrhagic acute pancreatitis after releasing the loop. Ser um amylase and lipase levels in the control group decreased gradually after releasing the loop, but the reductions were not significant. In both the group treated with KSG 504 intravenously and the group treate d subcutaneously, serum amylase and lipase levels decreased markedly u pon release of the loop in edematous acute pancreatitis. Furthermore, the histologic changes in edematous acute pancreatitis improved more r apidly than in the control group. However, no such biochemical or hist ologic evidence of improvement was observed in hemorrhagic acute pancr eatitis. The new cholecystokinin receptor antagonist, KSG 504, display ed a therapeutic effect in edematous acute pancreatitis but not in hem orrhagic acute pancreatitis. These findings suggest that endogenous ch olecystokinin release induced by the closed duodenal loop may have a c ontributory role in the development of edematous acute pancreatitis bu t not of hemorrhagic acute pancreatitis.