PHOSPHOLIPASE-C-GAMMA(1) IS PRESENT ON THE SURFACE OF HUMAN COLORECTAL-CANCER CELLS

Using murine monoclonal antibodies, we have detected the novel signal transducing enzyme, phospholipase C-gamma(1), on the surface of cultur ed human colorectal cancer cells. We have also demonstrated the presen ce of this enzyme on the surface of fresh human tumor cells derived fr om primary and metastatic colorectal tumors. This enzyme has previousl y been described to be associated only with the inner face of the plas ma membrane and the cell cytosol. The finding of an enzyme critical to the signal transduction pathway may have important implications for a dditional functions of this protein. (C) 1994 Academic Press, Inc.