We report the efficacy of combined chlorpromazine and electroconvulsiv
e therapy (ECT) in the treatment of mania. Two groups of 15 manic pati
ents received eight ECT sessions either actual or simulated, in a doub
le-blind, controlled study. All patients also received 600 mg of chlor
promazine daily until the sixth session. Results indicate that the gro
up receiving the combination of chlorpromazine and ECT did significant
ly better than the other group.