MULTIPLE EFFECTS OF 2,3-BUTANEDIONE MONOXIME

2,3-Butanedione monoxime, also known as diacetyl monoxime, is a nucleo philic agent which dephosphorylates acetylcholinesterase poisoned with organophosphates. This ''chemical phosphatase'' activity stimulated s tudies of the effect of 2,3-butanedione monoxime on phosphorylation-de pendent cellular processes. As a result of these studies, we know that the drug affects a number of mechanisms including muscle contraction, ionic current flow and synaptic transmission. Furthermore, it may be used as a component of cardioplegic solutions since it protects cardia c tissue exposed to certain ischaemic conditions. While this MiniRewie v reveals the diversity of its cellular actions, there continues to be unresolved questions regarding its molecular mechanism.