TRICLABENDAZOLE EFFECT ON FASCIOLA-HEPATI CA - INDUCED DECREASE OF BIOTRANSFORMATION LIVER-ENZYMES

Authors
JEMLI MH GALTIER P DORCHIES P BENROMDHANE S KILANI M
Citation
Mh. Jemli et al., TRICLABENDAZOLE EFFECT ON FASCIOLA-HEPATI CA - INDUCED DECREASE OF BIOTRANSFORMATION LIVER-ENZYMES, Revue de Medecine Veterinaire, 145(5), 1994, pp. 349-353
Citations number
25
Categorie Soggetti
Veterinary Sciences
Journal title
Revue de Medecine Veterinaire → ACNP
ISSN journal
00351555
Volume
145
Issue
5
Year of publication
1994
Pages
349 - 353
Database
ISI
SICI code
0035-1555(1994)145:5<349:TEOFC->2.0.ZU;2-0
Abstract
Eight lambs were experimentally infected by 200 metacercariae of Fasci ola hepatica. The exploration of biotransformation liver enzymes revea led led a decrease in microsomal cytochrome P450 concentration in infe cted animals. This decrease was confirmed by diminished monooxygenases , such as the N-demethylase activities and might reflect alteration of the liver tissue due to fluke migrations. A triclabendazole treatment after 6 weeks was effective but did not permit complete recovery of l iver enzyme activities.