SYNTHESES OF MORINDAPARVIN-A AND ITS DERIVATIVES

A general route for convergent syntheses of morindaparvin derivatives with 1,2-methylene-dioxyanthraquinone pattern is described. The anion of 2-methoxycyclohexanone (3), generated with lithium cyclohexylisopro pylamine at -78-degrees-C, was sulfenylated with phenyl phenylthiosulf onate followed by elimination to afford alpha, beta-unsaturated carbon yl system 8. 6-Methoxy-2-cyclohexen-1-one (8) was condensed with the f our phthalide sulfones derivatives 10a-d, to provide morindaparvin der ivatives, 1a-d.