A COMPARISON OF THE ANTIPYRETIC EFFICACY OF MEFENAMIC-ACID 125-MG SUPPOSITORY AND 60-MG SUSPENSION IN PEDIATRIC-PATIENTS AND AN EVALUATION OF THE LOCAL TOLERABILITY OF THE SUPPOSITORIES

This study evaluated the efficacy and safety of mefenamic acid supposi tories in 38 pediatric patients with fever. In Phase I, patients were randomly allocated to double-blind treatment with either a single mefe namic acid rectal suppository (125 mg) and a placebo oral suspension, or a single bioequivalent oral dose of mefenamic acid suspension (60 m g) and a placebo suppository. In Phase II, the patient received an act ive suppository every 6 hours, if required, to a maximum of three dose s. Patients in both Phase I treatment groups responded, with no statis tically significant differences between groups. The results demonstrat e that mefenamic suppositories are as effective for antipyretic purpos es as equivalent oral doses of mefenamic acid suspension, and that the suppositories are well tolerated.