Th. Elfaham, TRANSDERMAL DELIVERY OF BROMHEXINE HYDROCHLORIDE FROM VARIOUS FORMULATIONS THROUGH EXCISED HAIRLESS MOUSE SKIN, STP pharma sciences, 4(3), 1994, pp. 240-244
Bromhexine hydrochloride is a mucolytic agent. The drug helps in chron
ic bronchitis and chronic asthma. Due to its lipophilic nature and ext
ensive metabolism, it disappears quickly from the blood. The drug is k
nown to have some gastro-intestinal irritating effects. To overcome th
ese problems, the transdermal delivery of bromhexine hydrochloride mig
ht be a solution. In vitro skin permeation experiments across hairless
mouse skin revealed that water-soluble polyethylene glycol ointment e
xhibited the highest skin permeation potential which agreed with the i
n vitro release through a standard membrane. Bromhexine hydrochloride
release through a standard artificial membrane from water-soluble Gant
rez AN119 film preparation was higher than that from insoluble ethylce
llulose film preparation, but with experiments with the mouse skin, et
hylcellulose films showed higher permeation potentials. Natural permea
tion enhancers in ointments showed promising permeation enhancing effe
cts.