THE SYNTHESIS OF 2,2,4-TRISUBSTITUTED OXETANES AS NEW AZOLE ANTIFUNGAL AGENTS

Authors
RANE DF GIRIJAVALLABHAN VM PUAR MS SAKSENA AK LOEBENBERG D PARMEGIANI RM
Citation
Df. Rane et al., THE SYNTHESIS OF 2,2,4-TRISUBSTITUTED OXETANES AS NEW AZOLE ANTIFUNGAL AGENTS, Bioorganic & medicinal chemistry letters, 4(11), 1994, pp. 1313-1316
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
11
Year of publication
1994
Pages
1313 - 1316
Database
ISI
SICI code
0960-894X(1994)4:11<1313:TSO2OA>2.0.ZU;2-A
Abstract
Synthesis and biological activities of cis - and trans - 2,2,4 - trisu bstituted oxetanes 4 and 5 are described. The key diol intermediates 9 and 10 exhibited exceptionally good in vitro and in vivo antifungal a ctivity.