ANTIALLERGY AGENTS .3. ANGULAR TRICYCLIC ETHER DERIVATIVES OF THE 1,8-NAPHTHYRIDIN-2(1H)-ONE RING-SYSTEM

Authors
BLYTHIN DJ SHUE HJ CARLON E SPITLER J KREUTNER W
Citation
Dj. Blythin et al., ANTIALLERGY AGENTS .3. ANGULAR TRICYCLIC ETHER DERIVATIVES OF THE 1,8-NAPHTHYRIDIN-2(1H)-ONE RING-SYSTEM, Bioorganic & medicinal chemistry letters, 4(11), 1994, pp. 1327-1332
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
11
Year of publication
1994
Pages
1327 - 1332
Database
ISI
SICI code
0960-894X(1994)4:11<1327:AA.ATE>2.0.ZU;2-N
Abstract
The compounds described are potent, orally active inhibitors of the re lease of the leukotriene mediators of anaphylaxis in vitro and in vivo . Unlike most ''Mediator Release Inhibitors' (MRI's) described in the literature, they do not contain an acidic function.