POTENT, ACID-STABLE AND ORALLY-ACTIVE MACROLIDE-TYPE MOTILIN RECEPTORAGONISTS, GM-611 AND THE DERIVATIVES

Authors
KOGA H SATO T TSUZUKI K ONODA H KUBONIWA H TAKANASHI H
Citation
H. Koga et al., POTENT, ACID-STABLE AND ORALLY-ACTIVE MACROLIDE-TYPE MOTILIN RECEPTORAGONISTS, GM-611 AND THE DERIVATIVES, Bioorganic & medicinal chemistry letters, 4(11), 1994, pp. 1347-1352
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
11
Year of publication
1994
Pages
1347 - 1352
Database
ISI
SICI code
0960-894X(1994)4:11<1347:PAAOMM>2.0.ZU;2-6
Abstract
Based on the acid decomposition mechanism of erythromycin A, 1-deoxy-1 2-O-methyl-11-oxo-8.9-anhydroerythromycin A 6,9-hemiacetals were desig ned and synthesized. GM-611 (11) and the derivatives 8 and 10 were aci d-stable and showed potent in vitro and in vivo motilin agonistic acti vities, and these compounds were thought to be promising orally active prokinetic agents.