THE STRUCTURE OF METHIMAZOLE AND ITS CONSEQUENCES FOR CURRENT THERAPEUTIC MODELS OF GRAVES-DISEASE

Authors
GARNER M ARMSTRONG DR REGLINSKI J SMITH WE WILSON R MCKILLOP JH
Citation
M. Garner et al., THE STRUCTURE OF METHIMAZOLE AND ITS CONSEQUENCES FOR CURRENT THERAPEUTIC MODELS OF GRAVES-DISEASE, Bioorganic & medicinal chemistry letters, 4(11), 1994, pp. 1357-1360
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
11
Year of publication
1994
Pages
1357 - 1360
Database
ISI
SICI code
0960-894X(1994)4:11<1357:TSOMAI>2.0.ZU;2-Z
Abstract
NMR spectroscopy indicates that the structure of methimazole is best r epresented as a thione rather than as a thiol. This structure is predi cted by molecular orbital calculations to be the more stable form both in aqueous solution and in lipid. As a consequence, the use of Carbim azole and Propylthiouracil in the threatment of Graves' disease may re ly on the hitherto unconsidered chemistry of thiones rather than thiol s.