ADAMANTANE AND NIPECOTIC ACID-DERIVATIVES AS NOVEL BETA-TURN MIMICS

Authors
HOEKSTRA WJ PRESS JB BONNER MP ANDRADEGORDON P KEANE PM DURKIN KA LIOTTA DC MAYO KH
Citation
Wj. Hoekstra et al., ADAMANTANE AND NIPECOTIC ACID-DERIVATIVES AS NOVEL BETA-TURN MIMICS, Bioorganic & medicinal chemistry letters, 4(11), 1994, pp. 1361-1364
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
11
Year of publication
1994
Pages
1361 - 1364
Database
ISI
SICI code
0960-894X(1994)4:11<1361:AANAAN>2.0.ZU;2-M
Abstract
1,3-Adamantanediamine and nipecotic acid were used as scaffolds in des igning beta-turn peptide mimetic derivatives 3 and 5, respectively, ta rgeted as fibrinogen-GPIIB/IIA antagonists. The design focused on the 406-409 KQAG region of the gamma-chain of fibrinogen which appears as a beta-turn in solution NMR structures of Fg-gamma385-411.