D-AMINO ACIDS AS NOVEL P-2 P-3 LIGANDS FOR INHIBITORS OF HIV-1 PROTEASE/

Authors
SHEPHERD TA JUNGHEIM LN BAXTER AJ
Citation
Ta. Shepherd et al., D-AMINO ACIDS AS NOVEL P-2 P-3 LIGANDS FOR INHIBITORS OF HIV-1 PROTEASE/, Bioorganic & medicinal chemistry letters, 4(11), 1994, pp. 1391-1396
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
11
Year of publication
1994
Pages
1391 - 1396
Database
ISI
SICI code
0960-894X(1994)4:11<1391:DAANPP>2.0.ZU;2-0
Abstract
Noncoded D-amino acids have been synthesized which effectively replace the P2/P3 ligands of the HIV-1 protease inhibitor LY289612. Several a nalogues are shown to have potent enzyme inhibitory and antiviral acti vities.