SYNTHESIS OF FERROCENYL-SUBSTITUTED HETEROCYCLES - THE BENEFICIAL EFFECT OF THE MICROWAVE IRRADIATION

The synthesis of ferrocenyl-substituted thiophenes, furans, pyrroles, pyrimidine and pyrazole has been studied. 2-Ferrocenylpyrroles were pr epared from ferrocenyl ketoximes and acetylene in DMSO-KOH mixture whe reas 3-chloro-3-ferrocenylacrylaldehydes and thioglycolic or glycolic acids were the starting materials for the synthesis of tile thiophene and furan derivatives. The yields were significantly enhanced when the reactions were carried out in a microwave oven. The lower stability o f 2-ferrocenylfuran in comparison with 2-ferrocenylthiophene is discus sed on the basis of semiempirical quantum chemistry calculations.