SPIROCYCLIC DIPEPTIDES OF 1-AMINO-1-CYCLOHEXANECARBOXYLIC ACID

Spirocyclic cyclodipeptides with 1-amino-1-cyclohexanecarboxylic acid of the general formula cyclo(-Ach-A-), where A is Gly, L-Ala, D-Ala, L -Val, D-Val, L-Leu, D-Leu, D-Pgl, L-Phe or D-Phe, have been prepared b y cyclization of the corresponding linear dipeptide methyl esters. The peptides cyclo(-L- or D-Ala-Ach-), cyclo(-L-Val-Ach-) and cyclo(-D-Le u-Ach-) show higher activity in the Chick Embryotoxicity Screening Tes t when compared with derivatives containing 1-amino-1-cyclo-pentanecar boxylic acid or 1-amino-1-cyclobutanecarboxylic acid.