ANTITUBERCOLOTICS .66. NEW GROUPS OF POTENTIAL ANTITUBERCULOTICS - BIS(1-ARYLTETRAZOL-5-YL) DISULFIDES - STRUCTURE-ACTIVITY RELATIONSHIP

Authors
WAISSER K KUNES J HRABALEK A ODLEROVA Z
Citation
K. Waisser et al., ANTITUBERCOLOTICS .66. NEW GROUPS OF POTENTIAL ANTITUBERCULOTICS - BIS(1-ARYLTETRAZOL-5-YL) DISULFIDES - STRUCTURE-ACTIVITY RELATIONSHIP, Collection of Czechoslovak Chemical Communications, 59(1), 1994, pp. 234-238
Citations number
10
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
59
Issue
1
Year of publication
1994
Pages
234 - 238
Database
ISI
SICI code
0010-0765(1994)59:1<234:A.NGOP>2.0.ZU;2-R
Abstract
Oxidation of 1-aryltetrazole-5-thiols afforded bis(1-aryltetrazol-5-yl ) disulfides. The compounds were tested for antimycobactcrial activity against Mycobacterium tuberculosis, M. kansasii, M. avium and M. fort uitum. In the case of M. tuberculosis, the logarithm of minimum inhibi tory concentration showed a parabolic dependence on hydrophobic substi tuent constants. Although the compounds exhibited low to medium activi ty, the most active derivative, bis(4-chlorophenyltetrazol-5-yl) disul fide (III) was more effective against atypical strains than are the co mmercial tuberculostatics used as standards.