OCHRINDOLES-A-D - NEW BIS-INDOLYL BENZENOIDS FROM THE SCLEROTIA OF ASPERGILLUS-OCHRACEUS NRRL-3519

Four new prenylated bis-indolyl benzenoid metabolites (ochrindoles A-D ; 1-4) were isolated from antiinsectan organic extracts of the sclerot ia of Aspergillus ochraceus (NRRL 3519). The structures of these compo unds were determined primarily through HMBC, selective INEPT, and NOES Y experiments. These compounds displayed moderate activity in feeding assays against the corn earworm Helicoverpa zea and the dried fruit be etle Carpophilus hemipterus. Compounds 1-4 also exhibited activity aga inst Gram-positive bacteria.