ISOLATION OF ANTIRHINOVIRAL SESQUITERPENES FROM GINGER (ZINGIBER-OFFICINALE)

Authors
DENYER CV JACKSON P LOAKES DM ELLIS MR YOUNG DAB
Citation
Cv. Denyer et al., ISOLATION OF ANTIRHINOVIRAL SESQUITERPENES FROM GINGER (ZINGIBER-OFFICINALE), Journal of natural products, 57(5), 1994, pp. 658-662
Citations number
21
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
57
Issue
5
Year of publication
1994
Pages
658 - 662
Database
ISI
SICI code
0163-3864(1994)57:5<658:IOASFG>2.0.ZU;2-Q
Abstract
The dried rhizomes of Indonesian ginger, Zingiber officinale, were inv estigated for antirhinoviral activity in the plaque reduction rest. Fr actionation by solvent extraction, solvent partition, and repeated chr omatography guided by bioassay, allowed the isolation of several sesqu iterpenes with antirhinoviral activity. The most active of these was b eta-sesquiphellandrene [2] with an IC50 of 0.44 mu M vs. rhinovirus IB in vitro.